Prépublications

  1. S. Gazeau, X. Deng, E. Brunet-Ratnasingham, D.E. Kaufmann, C. Larochelle, P.A. Morel, J.M. Heffernan, C.L. Davis, A.M. Smith, A.L. Jenner, M. Craig. Using virtual patient cohorts to uncover immune response differences in cancer and immunosuppressed COVID-19 patients. bioRxiv.

  2. S. Farhang-Sardroodi, X. Deng, S. Portet, J. Arino, M. Craig. Insights into B cell and antibody kinetics against SARS-CoV-2 variants using mathematical modelling. bioRxiv.

  3. M. Getz, Y. Wang, G. An, A. Becker, C. Cockrell, N. Collier, M. Craig, C.L. Davis, J. Faeder, A.N. Ford Versypt, J.F. Gianlupi, J.A. Glazier, S. Hamis, R. Heiland, T. Hillen, D. Hou, M.A. Islam, A.L. Jenner, F. Kurtoglu, B. Liu, F. Macfarlane, P. Maygrundter, P.A Morel, A. Narayanan, J. Ozik, E. Pienaar, P. Rangamani, J.E. Shoemaker, A.M. Smith, P. Macklin. Rapid community-driven development of a SARS-CoV-2 tissue simulator. bioRxiv

Articles

  1. S. Messaoudi, K. Wai, A. Marple, S. Farzad Baniahmad, R.G. Wylie, M. Pelletier, M. Craig, Y. Durocher, A.A. Greschner, M.A. Gauthier. Rapid systematic screening of bispecific antibody surrogate geometries for T-cell engagement using DNA nanotechnology. Journal of the American Chemistry Society, 146(43): 29824-29835.. 2024. Publisher’s version.

  2. B. Mongeon, J. Hébert-Doutreloux, A. Surendran, E. Karimi, B. Fiset, D.F. Quail, L.A. Walsh, A.L. Jenner & M. Craig. Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies, npj Systems Biology and Applications, 10: 91. 2024. Publisher’s version.

  3. S. Linn, J. Ott-Moore, R. Shuttleworth, W. Zhang, M. Craig, A.L. Jenner. Deconstructing the contributions of heterogeneity to combination treatment of hormone sensitive breast cancer. In: Mathematical Modeling for Women’s Health - Collaborative Workshop for Women in Mathematical Biology. Eds: A. Ford Versypt, S. Blerta, R. Segal, S. Sindi. SpringerNature. 2024. Publisher’s version.

  4. J. Sheen, L. Curtin, S. Finley, A. Konstorum, R.B. McGee, M. Craig. Integrating diversity, equity, and inclusion into preclinical, clinical, and public health mathematical nodels. Bulletin of Mathematical Biology, 86: 56. 2024. Publisher’s version.

  5. M. Brunetti, I.A. Iasenza, A.L. Jenner, N.J.M. Raynal, K. Eppert, M. Craig. Mathematical modelling of clonal reduction therapeutic strategies in acute myeloid leukemia, Leukemia Research, 140: 107485. 2024. Publisher’s version.

  6. R.S. Shabman, M. Craig, R. Laubenbacher, D. Reeves & L.L. Brown. NIAID/SMB workshop on multiscale modeling of infectious and immune-mediated diseases. Bulletin of Mathematical Biology, 86(44). 2024. Publisher’s version.

  7. D. Fournelle, F. Mostefai, E. Brunet-Ratnasingham, R. Poujol, J.-C. Grenier, J.H. Gálvez, A. Pagliuzza, I. Levade, S. Moreira, M. Benlarbi, G. Beaudoin-Bussières, G. Gendron-Lepage, C. Bourassa., A. Tauzin, S. Grandjean Lapierre, N. Chomont, A. Finzi, D.E. Kaufmann, M. Craig, J. Hussin. Intra-host evolution analyses in an immunosuppressed patient supports SARS-CoV-2 viral reservoir hypothesis, Viruses, 16(3):342. 2024. Publisher’s version.

  8. J. Le Sauteur-Robitaille, P. Crosley, M. Hitt, A.L. Jenner, M. Craig. Mathematical modelling predicts pathways to successful implementation of combination TRAIL-producing oncolytic virus and PAC-1 to treat granulosa cell tumours of the ovary. Cancer Biology and Therapy, 24(1). 2023. Publisher’s version.

  9. X. Deng, P. Gantner, J. Forestell, A. Pagliuzza, E. Brunet-Ratnasingham, M. Durand, D.E. Kaufmann, N. Chomont, M. Craig. Plasma SARS-CoV-2 RNA elimination and RAGE kinetics distinguish COVID-19 severity. Clinical & Translational Immunology, 12: e1468. 2023. Publisher’s version.

  10. A. Surendran, J. Le Sauteur-Robitaille, D. Kleimeier, J. Gevertz, K. Wilkie, A.L. Jenner, M. Craig. Approaches to generating virtual patient cohorts with applications in oncology. In: Cesario, A., D'Oria, M., Auffray, C., Scambia, G. (eds) Personalized Medicine Meets Artificial Intelligence. Springer, Cham. Publisher’s version.

  11. A. Surendran, A.L. Jenner, E. Karimi, B. Fiset, D.F. Quail, L.A. Walsh, M. Craig. Agent-based modelling reveals the role of the tumour microenvironment on the short-term success of combination temozolomide/immune checkpoint blockade to treat glioblastoma. Journal of Pharmacology and Experimental Therapeutics, 387(1): 66-77. 2023. Publisher’s version.

  12. M. Craig, J. Gevertz, I. Kareva, K.P. Wilkie. A practical guide for the generation of model-based virtual clinical trials. Frontiers in Systems Biology, 3. 2023. Publisher’s version.

  13. R. Lui, M. Craig, D.Z. D’Argenio, A. Betts, D.E. Mager, T.S. Mauer. Editorial: Model-informed decision making in the preclinical stages of pharmaceutical research and development. Frontiers in Pharmacology, 14: 1184914. 2023. Publisher’s version.

  14. S. Forest, J. Coutu, J.M. Montiel-Leon, I. Beniani, Z.S. Yu, M. Craig, J.F. Masson. Prediction of maple syrup quality from maple sap with a plasmonic tongue and ordinal mixed-Effects modeling. ACS Food Science & Technology, 3(4): 635-647. 2023. Publisher’s version.

  15. J.F. Ndiaye, F. Nekka, M. Craig. Understanding the mechanisms and treatment of heart failure: quantitative systems pharmacology models with a focus on SGLT2 inhibitors and sex-specific differences. Pharmaceutics, 15(3): 1002. 2023. Publisher’s version.

  16. S. Gholami, C.S. Korosec, S. Farhang-Sardroodi, D.W. Dick, M. Craig, M.S. Ghaemi, H.K. Ooi, J.M. Heffernan. A mathematical model of protein subunits COVID-19 vaccines. Mathematical Biosciences, 358: 108970. 2023. Publisher’s version.

  17. S. Gazeau, X. Deng, H.K. Ooi, F. Mostefai, J. Hussin, J. Heffernan, A.L. Jenner, M. Craig. The race to understand immunopathology in COVID-19: perspectives on the impact of quantitative approaches to understand within-host interactions. ImmunoInformatics, 9, 100021. 2023. Publisher’s version.

  18. C. Korosec, S. Farhang-Sardroodi, D.W. Dick, S. Gholamei, M.S. Ghaemi, I.R. Moyles, M. Craig, H.K. Ooi, J.M. Heffernan. Long-term predictions of humoral immunity after two doses of BNT162b2 and mRNA-1273 vaccines based on dosage, age and sex. Scientific Reports, 12, 21232. 2022. Publisher’s version.

  19. O. Cardinal, C. Burlot, Y. Fu, P. Crosley, M. Hitt, M. Craig, A.L. Jenner. Establishing combination PAC-1 and TRAIL regimens for treating ovarian cancer based on patient-specific pharmacokinetic profiles using in silico clinical trials. Computational and Systems Oncology, 2(2), e1035. 2022. Publisher’s version.

  20. H. Zhang, M. Chien, Y. Hou, W. Shomali, R. Brar, C. Ho, P. Han, D. Xu, B.M. Zhang, X. Guo, L. Tolentino, N.C. Wu, A.G. Tsai, J. Jin, W. Holbrook Witteles, Z. Chen, P. Abidi, D. Jangam, M.S. Krieger, M. Craig, J.B. Bussel, J.R. Gotlib, J.L. Zehnder. Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3, and MPL mutations. Blood Advances, 7(1), 190-194. 2023. Publisher’s version.

  21. A.L. Jenner, M. Smalley, D. Goldman, W.F. Goins, C.S. Cobbs, R.B. Puchalski, A.E. Chiocca, S. Lawler, P. Macklin, A. Goldman, M. Craig. Agent-based computational modelling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy. iScience, 25(6), 104395. 2022. Publisher’s version.

  22. A. Uthamacumaran and M. Craig. Algorithmic reconstruction of glioblastoma network complexity. iScience, 25(5), 104179. 2022. Publisher’s version.

  23. S. Farhang-Sardroodi, M. Ghaemi, M. Craig, H.K. Ooi, J.M. Heffernan. A machine learning approach to differentiate between COVID-19 and influenza infection using synthetic infection and immune response data. Mathematical Biosciences and Engineering, 19(6), 5813-5831. 2022. Publisher’s version.

  24. J. Ferrari Gianlupi, T. Mapder, T.J. Sego, J.P. Sluka, S.K. Quinney, M. Craig, R.E. Stratford, Jr., and J.A. Glazier. Multiscale model of antiviral timing, potency, and heterogeneity effects on an epithelial tissue patch infected by SARS-CoV-2. Viruses, 14(3), 605. 2022. Publisher’s version.

  25. A. Sharma, M. Elharram, J. Afilalo, A. Flannery, M. Afilalo, C. Tselios, J. Ni, J.A. Ezekowitz, M.P. Cheng, A.P. Ambrosy, F. Zannad, J. Brophy, N. Giannetti, A. Bessissow, N. Kronfli, A. Marelli, H. Aziz, M. Alqahtani, M. Aflaki, M. Craig, R.D .Lopes, J.P. Ferreira. A randomized controlled trial of renin-angiotensin-aldosterone system inhibitor management in patients admitted in hospital with COVID-19. American Heart Journal, 247, 76-89. 2022. Publisher’s version.

  26. F. Mostefai, I. Gamache, J. Huang, A. N'Guessan, J. Pelletier, A. Pesaranghader, D. Hamelin, C.L. Murall, R. Poujol, J.C. Grenier, M. Smith, E. Caron, M. Craig, J. Shapiro, G. Wolf, S. Krishnaswamy, and J. Hussin. Population genomics approaches for genetic characterization of SARS-CoV-2 lineages. Frontiers in Medicine, 9. 2022. Publisher’s version.

  27. T. Cassidy, D. Nichols, M. Robertson-Tessi, M. Craig, A.R.A. Anderson. The role of memory in non-genetic inheritance and its impact on cancer treatment resistance. PLOS Computational Biology, 17(8), e1009348. 2021. Publisher’s version.

  28. R.V. Paredes Bonilla, F. Nekka, M. Craig. A quantitative systems pharmacology framework for optimal doxorubicin granulocyte colony-stimulating factor regimens in triple-negative breast cancer. Pharmacology, 106(9-10), 542-550. 2021. Publisher’s version.

  29. S. Farhang-Sardroodi, C. Korosec, S. Gholami, M. Craig, I.R. Moyles, M.S. Ghaemi, H.K. Ooi, J.M. Heffernan. Analysis of host immunological response of adenovirus-based COVID-19 vaccines. Vaccines, 9(8), 861. 2021. Publisher’s version.

  30. J. Le Sauteur-Robitaille, Z.S. Yu, M. Craig. Impact of estrogen population pharmacokinetics on a QSP model of mammary stem cell differentiation into myoepithelial cells. AIMS Mathematics, 6(10), 10861-10880. 2021. Publisher’s version.

  31. A.L. Jenner, R.A. Aogo, S. Alfonso, V. Crowe, X. Deng, A.P. Smith, P.A. Morel, C.L. Davis, A.M. Smith, M. Craig. COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes. PLOS Pathogens, 17(7), e100975. 2021. Publisher’s version.

  32. M. Brunetti, M.C. Mackey, M. Craig. Understanding normal and pathological hematopoietic stem cell biology using mathematical modelling. Current Stem Cell Reports, 7, 109–120. 2021. Publisher’s version.

  33. P. Crosley, A. Farkkila, A.L. Jenner, C. Burlot, O. Cardinal, K.G. Potts, K. Agopsowicz, M. Pihlajoki, M. Heikinheimo, M. Craig, Y. Fu, M.M. Hitt. Procaspase-Activating Compound-1 synergizes with TRAIL to induce apoptosis in established granulosa cell tumor cell line (KGN) and explanted patient granulosa cell tumor cells in vitro. International Journal of Molecular Sciences, 22(9), 4699. 2021. Publisher’s version.

  34. A. Heyde, D. Rohde, C.S. McAlpine, S. Zhang, F.F. Hoyer, J.M. Gerold, D. Cheek, Y. Iwamoto, M.J. Schloss, K. Vandoorne, O. Iborra-Egea, C. Muñoz-Guijosa, A. Bayes-Genis, J.G. Reiter, M. Craig, F.K. Swirski, M. Nahrendorf, M.A. Nowak, K. Naxerova. Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell, 184(5), 1348-1361.e22. 2021. Publisher’s version.

  35. M. Aflaki, A. Flannery, J.P. Ferreira, M. Pellan Cheng, N. Kronfli, A. Marelli, F. Zannad, J. Brophy, J. Afillalo, T. Huynh, N. Giannetti, A. Bessissow, J.A. Ezekowitz, R.D. Lopes, A.P. Ambrosy, M. Craig, A. Sharma. Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial. Trials, 22, 115. 2021. Publisher’s version.

  36. A.L. Jenner, T. Cassidy, K. Belaid, M-C Bourgeois-Daigneault, M. Craig. In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity. Journal for ImmunoTherapy of Cancer, 9, e001387. 2021. Publisher’s version

  37. M. Craig, A.L. Jenner, B. Namgung, L.P. Lee, A. Goldman. Engineering in medicine to address the challenge of cancer drug resistance: from micro- and nanotechnologies to computational and mathematical modeling. Chemical Reviews, 121(6), 3352–3389. 2021. Publisher's version

  38. M.C. Mackey, S.Glisovic, J-M. Leclerc, Y. Pastore, M. Krajinovic, M. Craig. The timing of cyclic cytotoxic chemotherapy can worsen neutropenia and neutrophilia. British Journal of Clinical Pharmacology, 87, 687– 693. 2021. Publisher's version

  39. S. Alfonso, A.L. Jenner, M. Craig. Translational approaches to treating dynamical diseases through in silico clinical trials. Chaos, 30, 123128. 2020. Publisher’s version

  40. M.S. Krieger, J.M. Moreau, H. Zhang, M. Chien, J.L. Zehnder, M. Craig. A blueprint for identifying phenotypes and drug targets in complex disorders with empirical dynamics. Patterns, 1(9), 100138. 2020. Publisher's version

  41. A.L. Jenner, R.A. Aogo, C.L. Davis, A.M. Smith, M. Craig. Leveraging computational modeling to understand infectious diseases. Current Pathobiology Reports, 8, 149–161. 2020. Publisher's version

  42. T. Cassidy, A.R. Humphries, M. Craig*, M.C. Mackey*. Characterizing chemotherapy-induced neutropenia and monocytopenia through mathematical modelling. Bulletin of Mathematical Biology, 82, 104. 2020. Publisher's version *Co-senior authors

  43. T. Cassidy, M. Craig. Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization. PLOS Computational Biology, 15(11), e1007495. 2019. Publisher's version

  44. M. Craig, K. Kaveh, A. Woosley, D. Goldman, E. Eton, R.M. Mehta, A. Dhawan, K. Arai, M.M. Rahman, S. Chen, M.A. Nowak, A. Goldman. Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer. PLOS Compututational Biology , 15(8), e1007278. 2019. Publisher's version
    Featured as the August journal cover

  45. T. Cassidy, M. Craig, A.R. Humphries. Equivalences between age structured models and state dependent distributed delay differential equations. Mathematical Biosciences and Engineering, 16(5), p. 5419-5450. 2019. Publisher's version

  46. N. Pillai, M. Craig, A. Dokoumetzidis, S.L. Schwartz, R. Bies, I. Freedman. Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: Estimating tumor antigenicity in a model of immunotherapy. Progress in Biophysics and Molecular Biology , 139, p. 23-30. 2018. Publisher's version

  47. A.R. Kirtane, O. Abouzid, D. Minaham, T. Bensel, A.L. Hill, C. Selinger, A. Bershteyn, S.S. Mo, M. Craig, H. Mazdiyasni, C. Cleveland, J. Rogner, Y-A. Lee, L. Booth, F. Javid, T. Grant, A.M. Bellinger, B. Nikolic, A. Hayward, L. Wood, P.A. Eckhoff, M. A. Nowak, R. Langer, and G. Traverso. Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy. Nature Communications, 9(1), p. 12. 2018. Publisher's version

    Coverage by BBC, Coverage by NPR

  48. D. Câmara De Souza*, M. Craig*, T. Cassidy, J. Li, F. Nekka, J. Bélair, and A. R. Humphries. Transit and lifespan in neutrophil production: implications for drug intervention. Journal of Pharmacokinetics and Pharmacodynamics, 45(1), p. 59-77. 2018. Publisher's version [*=Co-first authors]

  49. G.P. Langlois, M Craig, A. R. Humphries, M. C. Mackey, J.M. Mahaffy, J Bélair, T Moulin, S.R. Sinclair, and L. Wang. Normal and pathological dynamics of platelets in humans. Journal of Mathematical Biology, 75, 6-7, p. 1141-1462. 2017. Publisher's version

  50. M. Craig. Towards quantitative systems pharmacology models of chemotherapy-induced neutropenia. CPT: Pharmacometrics & Systems Pharmacology, 6(5), p. 293-304. 2017. Publisher's version

  51. M. Craig, A.R. Humphries, and M.C. Mackey. An upper bound for the half-removal time of neutrophils from the blood. Blood, 128, 15, p. 1989-1991. 2016. Publisher's version

  52. M. Craig, M. González-Sales, J. Li, and F. Nekka. Approaching Pharmacometrics as a Paleontologist Would: Recovering the Links Between Drugs and the Body Through Reconstruction. CPT: Pharmacometrics & Systems Pharmacology, 5(3), p. 158-160. 2016. Publisher's version

  53. M. Craig, M. González-Sales, J. Li, and F. Nekka. Impact of Pharmacokinetic Variability on a Mechanistic Physiological Pharmacokinetic/Pharmacodynamic Model: A Case Study of Neutrophil Development, PM00104, and Filgrastim. In Mathematical Sciences with Multidisciplinary Applications, edited by B. Toni, p. 91-112. New York: Springer Science + Business Media. 2016. Publisher's version

  54. M. Craig, A. R. Humphries, and M. C. Mackey. A Mathematical Model of Granulopoiesis Incorporating the Negative Feedback Dynamics and Kinetics of G-CSF/Neutrophil Binding and Internalization. Bulletin of Mathematical Biology, 78(12), p. 2304-2357. 2016. Publisher's version
    Awarded the Lee A. Segal Prize for Best Student Paper by the Society for Mathematical Biology

  55. M. Craig, A.R. Humphries, F. Nekka, J. Bélair, J. Li, and M.C. Mackey. Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: Mathematical modelling guides dose optimisation to minimise neutropenia. Journal of Theoretical Biology, 385, p. 77-89. 2015. Publisher's version